胆囊切除术对血脂和脂蛋白水平的影响Effect of cholecystectomy on plasma lipid a...

Effect of cholecystectomy on plasma lipid and lipoprotein levels

Effect of cholecystectomy on plasma lipid and lipoprotein levels.pdf (446.23 KB, 下载次数: 7)

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• 标题： Effect of cholecystectomy on plasma lipid and lipoprotein levels.
• 作者：Juvonen TKervinen KKairaluoma MIKesäniemi YA
• 杂志：Hepato-gastroenterology 42(4):377-82.
  

胆囊切除术对血脂和脂蛋白水平的影响。
JuvonenŢ ， Kervinen K表 ， Kairaluoma MI ， KesäniemiYA 。
外科部，奥卢大学。

摘要
本研究的目的是要阐明一个常见的手术，胆囊切除术的效果，对血脂和脂蛋白的浓度。连续19个病人症状的胆结石病和排空胆囊，和16个对照组（尼森罗塞蒂胃底折叠术）进行了研究。各种脂蛋白的胆固醇，甘油三酯，和蛋白质浓度进行了分析。血浆总胆固醇和低密度脂蛋白胆固醇水平显着降低，胆囊切除术的患者（P = 0.0048，P = 0.0239），手术后第3天，随后恢复至术前水平。在对照组患者观察到类似的趋势，总胆固醇和低密度脂蛋白胆固醇水平，但这些变化并未达到统计意义。注意到在胆囊切除术患者的一个显着增加，极低密度脂蛋白和中间密度脂蛋白载脂蛋白B的浓度在手术后三年（P = 0.0019，P = 0.0001）。这些微小的变化血浆脂蛋白胆囊切除术是不会有任何的发展冠状动脉心脏疾病的重要性。然而，他们指出，胆固醇代谢的改变肠切除胆囊后。
Effect of cholecystectomy on plasma lipid and lipoprotein levels.
Juvonen T , Kervinen K , Kairaluoma MI , Kesäniemi YA .

Department of Surgery, University of Oulu.

Abstract
This study was designed to elucidate the effect of cholecystectomy, a common surgical procedure, on the concentrations of plasma lipids and lipoproteins. 19 consecutive patient with symptomatic gallstone disease and emptying gallbladder, and 16 control patients (Nissen-Rosetti fundoplication) were studied. Cholesterol, triglyceride, and protein concentrations of various lipoproteins were analysed. Plasma total and LDL cholesterol levels were significantly reduced in cholecystectomy patients (p = 0.0048 and p=0.0239) at day 3 after the operation, the values returning to the preoperative level thereafter. In the control patients similar trends were observed for total and LDL cholesterol levels but these changes did not reach statistical significance. In cholecystectomy patients a significant increase was noticed in the very-low-density lipoprotein and intermediate density lipoprotein apoprotein B concentration three years after surgery (p= 0.0019 and p=0.0001). These minor changes in plasma lipoproteins following cholecystectomy are unlikely to have any importance in the development coronary heart disease. They indicate, however, altered enterohepatic metabolism of cholesterol after the removal of the gallbladder.

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