阴道上皮内瘤变

阴道上皮内瘤变（VAIN）是一种疾病，描述了以增生异常改变为特征的阴道恶性组织学发现。[1]



这种疾病很罕见，通常没有症状。[2] 在Papanicolaou测试（巴氏涂片）中可通过异常细胞的存在来检测VAIN。[2]

就像宫颈上皮内瘤变一样，VAIN分为三个阶段，VAIN 1、2和3。[3] 在VAIN 1中，阴道皮肤细胞厚度的三分之一异常，而在VAIN 3中，整个厚度受到影响。[3] VAIN 3也称为原位癌或0期阴道癌。[3]

感染某些类型的人乳头瘤病毒（“高危类型”）可能与多达80％的VAIN病例有关。[4] 已证明在初次性接触之前给女孩接种HPV疫苗可减少VAIN发生率。[5]

参考
Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 1192. ISBN 978-1-4160-2999-1.
Diakomanolis, E; Stefanidis, K; Rodolakis, A; Haidopoulos, D; Sindos, M; Chatzipappas, I; Michalas, S (2002). "Vaginal intraepithelial neoplasia: report of 102 cases". European Journal of Gynaecological Oncology. 23 (5): 457–9. PMID 12440826.
Cancer Research UK (2002). The stages of cancer of the vagina Archived 2007-10-07 at the Wayback Machine. CancerHelp UK. Retrieved January 3, 2008.
Cancer Research UK (2002). Risks and causes of vaginal cancer Archived 2007-10-07 at the Wayback Machine. CancerHelp UK. Retrieved January 3, 2008.
"FDA Approves Expanded Uses for Gardasil to Include Preventing Certain Vulvar and Vaginal Cancers". 2008-09-12. Retrieved 2010-02-13.