择期腹腔镜胆囊切除术预防性应用抗生素的作用

择期腹腔镜胆囊切除术预防性应用抗生素的作用

作者：乌鲁达，穆罕默德，Gurkan Yetkin; Citgez，比伦特埃杰
来源： JSLS，中国的社会Laparoendoscopic外科医生，第13卷，第3号月- 2009年9月，第337-341页（5）
发布者：Laparoendoscopic外科医生协会

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摘要：
背景与目的：选修腹腔镜胆囊切除术具有感染性并发症的风险较低，但许多医生仍然使用预防性抗生素。这项前瞻性研究的目的是调查的必要性和测试在低风险的腹腔镜胆囊切除术的病人术后感染等并发症的预防性应用抗生素的疗效。
方法：低危患者，随机分成2组：68例（第1组），麻醉诱导后静脉注射头孢唑啉1克（第2组）和76例未给予预防性应用抗生素。在这两个群体，化脓性并发症进行记录和比较。
结果：正胆汁培养和胆囊破裂手术部位感染并没有显着增加的速度。在第1组中，有3例（4.41％），伤口感染，肺部感染3例（4.41％），1（1.47％）的情况下尿路感染。在第2组中，有2例（2.63％），伤口感染，2例（2.63％）和肺部感染，尿路感染3例（3.95％）的情况下。并发症的发生率没有显着的差异存在。
结论：根据我们的数据，预防性使用抗生素并不能减少术后感染等并发症和手术部位感染的速度，在低风险的患者，腹腔镜胆囊切除术是没有必要的。

The Role of Prophylactic Antibiotics in Elective Laparoscopic Cholecystectomy
Authors: Uludag, Mehmet; Yetkin, Gurkan; Citgez, Bulent
Source: JSLS, Journal of the Society of Laparoendoscopic Surgeons, Volume 13, Number 3, July - September 2009 , pp. 337-341(5)
Publisher: Society of Laparoendoscopic Surgeons

Abstract:
Background and Objectives: Elective laparoscopic cholecystectomy has a low risk for infectious complications, but many surgeons still use prophylactic antibiotics. The aim of this prospective study was to investigate the necessity and test the efficacy of prophylactic antibiotics on postoperative infection complications in low-risk patients undergoing laparoscopic cholecystectomy.
Methods: Low-risk patients were randomly placed into 2 groups: 68 patients (group 1) received cefazolin 1g intravenously after induction of anesthesia, and 76 patients (group 2) were not given prophylactic antibiotics. In both groups, septic complications were recorded and compared.
Results: Positive bile culture and gallbladder rupture did not significantly increase the rate of surgical site infections. In group 1, there were 3 (4.41%) cases of wound infection, 3 (4.41%) cases of pulmonary infections, and 1 (1.47%) case of urinary tract infection. In group 2, there were 2 (2.63%) cases of wound infection, 2 (2.63%) case of pulmonary infections, and 3 (3.95%) cases of urinary tract infection. No significant difference existed in the complication rates.
Conclusions: Based on our data, the use of prophylactic antibiotics does not decrease the rate of postoperative infection complications and surgical-site infections and is not necessary in low-risk patients undergoing laparoscopic cholecystectomy.