胃窦切除术

Antrectomy

                               
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Antrectomy

Definition

An antrectomy is the resection, or surgery, of the main stomach referred to as antrum. The antrum may be the lower third from the stomach that lies between patient’s body from the stomach and also the pyloric canal, which empties to the first the main small intestine. It's also referred to as antrum pyloricum or even the gastric antrum. Because an antrectomy may be the elimination of some from the stomach, frequently it's known as an incomplete or subtotal gastrectomy.

Purpose

An antrectomy might be carried out to deal with a number of different problems that get a new digestive tract:

• Peptic ulcer disease (PUD). An antrectomy might be completed to treat difficulties from ulcers which have not taken care of immediately treatment. These problems include out of control or continual bleeding and obstructions that prevent food from passing to the small intestine. Since the antrum creates gastrin, the industry hormone that energizes the manufacture of gastric acid, its elimination lowers the amount of acid secretions within the stomach.
• Cancers from the digestive system and nearby organs. An antrectomy might be carried out not just to remove a malignant gastric ulcer, but additionally to alleviate pressure about the lower end from the stomach brought on by cancers from the pancreas, gallbladder, or liver.
• Arteriovenous malformations (AVMs) from the stomach. AVMs are selections of small arteries that could create in a variety of areas of this enzymatic system. AVMs may cause bleeding to the gastrointestinal tract, leading to hematemesis (vomiting blood) or melena (black or tarry stools containing blood). The kind of AVM probably to happen within the antrum is called gastric antral vascular ectasia (GAVE) syndrome. The dilated arteries in GAVE create reddish streaks about the wall from the antrum that appear to be such as the stripes on the watermelon.
• Gastric outlet obstruction (GOO). GOO isn't just one disease or ailment but an ailment where the stomach cannot empty since the pylorus is obstructed. Within 37% of cases, the reason for the blockage is benign-most often PUD, gallstones, bezoars, or scarring brought on by ingestion of hydrochloric acid or other caustic substance. Another 63% of cases come from pancreatic cancer, gastric cancer, or other malignancy which has spread towards the digestive system.
• Penetrating gunshot or stab wounds which have induced extreme harm to the duodenum and pancreas. An antrectomy might be done being an emergency measure once the arteries supplying the duodenum happen to be damaged.
  

Description

At the moment just about all antrectomies are carried out as open procedures, which imply that they're carried out by a sizable incision within the patient's abdomen using the patient under general anesthesia. Following the patient is anesthetized, a urinary catheter is positioned to watch urinary output and along with a nasogastric tube is placed. Following the patient's abdomen continues to be cleansed by having an antiseptic, the doctor constitutes a large incision in the patient's rib cage towards the navel. After isolating the overlying layers of tissue, the doctor reveals the stomach. One clamp is positioned in the budget and another clamp somewhat higher, dividing from the lower third from the stomach. A cutting stapler enables doctor to take away the lower third (the antrum) and fix top of the part of the stomach towards the small intestine. Following the stomach and intestine happen to be reattached, the region is rinsed with saline solution and also the incision closed.

• Most antrectomies are carried out as well as a vagotomy. This can be a treatment where the doctor cuts various branches from the vagus nerve, which bears messages in the brain towards the stomach to secrete more gastric acid. The doctor might want to execute a selective vagotomy to be able to disable the branches from the nerve that govern gastric secretion without cutting the branches that manage stomach emptying.
• Some doctors have carried out antrectomies having a laparoscope, which is less invasive kind of surgery.
  

Demographics

Based on the Centers for Disease Control (CDC), about 10% of Americans will build up an ulcer within the stomach or duodenum at some stage in their life. Peptic ulcer disease (PUD) is rather common within the general USA population. Four million adults are clinically diagnosed or treated every year for PUD; tens of thousands of is going to be hospitalized for treatment; and 40,000 may have surgery to have an ulcer-related condition. About 6,500 Americans die every year from problems associated with PUD. GAVE, or watermelon stomach, is an extremely rare reason for gastrointestinal bleeding which was first identified in 1952. It's been related to such disorders as scleroderma, cirrhosis from the liver, familial Mediterranean fever, and cardiovascular disease. GAVE affects women better than two times as frequently men. It will always be based in the elderly; the typical age at diagnosis is 75 in females and 70 in males. Peptic ulcers can be cultivated at all ages. Duodenal ulcers tend to be more common in males, and gastric ulcers tend to be more experienced by women too. Other risk factors for PUD include heavy smoking along with a genealogy of either duodenal or gastric ulcers.

Preparation/Diagnosis

Preparation

Preparation to have an antrectomy needs tests to judge the patient's all around health and fitness for surgery. These tests have an EKG, x-rays and blood tests, along with a urine test. The individual is questioned to discontinue aspirin along with other blood-thinning medicines in regards to a week before surgery. No solid food or liquid ought to be taken after midnight till the evening before surgery. In many hospitals the individual will be presented a sedative prior to the operation either intravenously or by injection. The overall anesthesia is offered within the operating room.

Diagnosis

Proper diagnosis of PUD along with other stomach disorders starts with using the patient's history, including a household history. Oftentimes the patient's doctor will order tests to be able to narrow diagnosing. When the patient is older or has lost a lot of weight recently, a doctor will think about the chance of gastric cancer. When there is past duodenal or gastric ulcers within the patient's family, a doctor may inquire concerning the kind of soreness the individual is going through. Pain related to duodenal ulcers often takes place through the night, is relieved at mealtimes, but reappears 2 to 3 hours after consuming. Pain from gastric ulcers, however, might be compounded by eating and associated with nausea and vomiting. Occurrence of vomiting repeatedly soon after eating suggests a gastric obstruction. The most typical diagnostic tests for stomach problems are:

• Endoscopy. An endoscope is really a thin bendable tube having a source of light and camera on a single end that may be passed with the throat and mouth to be able to consider within the upper digestive system. The recording camera connected to the endoscope projects images on the screen that permit a doctor to determine ulcers, tissue growths, along with other potential problems. The endoscope may be used to collect tissue cells for any cytology analysis, or perhaps a small tissue sample for any biopsy. A tissue biopsy may be used to test for the presence of Helicobacter pylori, a spiral bacterium which was discovered in 1982 to become the actual reason for most gastric ulcers, in addition to try for cancer. Endoscopy is among the best tests for diagnosing AVMs.
• Double-contrast barium x-ray study from the upper gastrointestinal tract. This test may also be called a maximum GI series. The individual is offered a liquid type of barium to consider orally. The barium coats the tissues lining the esophagus, stomach, and small intestine, letting them be viewed more certainly with an x-ray. The radiologist may also watch the barium since it moves with the digestive tract to be able to target the location of obstruction.
• Urease breathe test. This test may be used to monitor the results of ulcer treatment in addition to identify the existence of H. pylori. The individual is offered urea labeled with either carbon 13-C or 14-C. H. pylori delivers urease, that will break up the urea within the test dose to ammonia and co2 that contains the labeled carbon. The co2 containing the labeled carbon may then be discovered within the patient's breath.
  

Who performs the process and where could it be carried out?

An antrectomy is conducted being an inpatient process inside a hospital. It is almost always carried out with a specialist in gastrointestinal surgical procedures or surgical oncology.

Morbidity and mortality rates

The death rate for antrectomies associated with ulcer treatment methods are about 1-2%; for antrectomies associated with gastric cancer, 1%-3%.
The rates of additional complications related to antrectomies for ulcer treatment are:

• Recurrence of ulcer: 1%-1.5%.
• Diarrhea: 12%.
• Dumping syndromes: 30%-35%.
  

Risks

Along with earlier or later dumping syndrome, other risks related to antrectomies include:

• Dysphagia. Dysphagia, or soreness in swallowing, may take place after an antrectomy when digestive juices in the duodenum flow upward to the esophagus and irritate its lining.
• Diarrhea. This problem is much more prone to exist in patients who were built with a vagotomy in addition to an antrectomy.
• Recurrence of gastric ulcers.
• Malabsorption/malnutrition. Iron-deficiency anemia, folate deficiency, and lack of calcium sometimes take place after an antrectomy because gastric acid is essential for iron to become assimilated from food.
• Weight loss. About 30-60% of patients who may have had a mixed antrectomy/vagotomy slim down after surgery. The most typical reason for weight reduction is decreased intake of food because of the smaller size the stomach. In some instances, however, the individual loses weight since the nutrients within the food aren't being assimilated through the body.
• Bezoar development. Bezoars are collections of foreign material within the stomach that may prevent the passage of food to the small intestine. They might produce after an antrectomy when the patient is consuming foods full of plant fiber or perhaps is not chewing them completely.
  

Normal results

Normal outcomes of an antrectomy rely on the reason why for that surgery. Antrectomies carried out to lessen acid secretion in PUD in order to take out premalignant tissue to avoid gastric cancer are gone 95% successful. The effectiveness is even higher for watermelon stomach. Antrectomies performed to deal with gastric cancer or penetrating abdominal trauma are less successful, but this result's associated with the seriousness of the patient's illness or injury as opposed to the surgical treatment itself.

Questions a patient should ask a doctor

• What is the opinion of laparoscopic antrectomies?
• What would be the options to an antrectomy for a patient’s condition? Which may a physician suggests and why?
• How likely patients to build up dumping syndrome basically possess the procedure?
• How many antrectomies perhaps a doctor has carried out?
  

Aftercare

Aftercare within the hospital to have an antrectomy is comparable to the aftercare presented for other operations relating to the abdomen, when it comes to incision care, pain medicine and antibiotics to reduce the chance of infection. Healing in patient’s own home typically takes many weeks. The individual is offered an endoscopic check-up about 6 to 8 weeks after surgery. The most crucial facet of aftercare following an antrectomy is consideration to diet and diet plan. About 30% of patients who may have had an antrectomy or perhaps a full gastrectomy evolves what's referred to as dumping syndrome. Disposal syndrome results from food leaving the stomach prematurely following a meal and being "dumped" to the small intestine. There are two kinds of dumping syndrome, early and late. Early dumping develops 10-20 minutes after meals and it is seen as feelings of nausea, faintness, sweating, a pounding heart, rapid heartbeat, and abdominal cramps. Late dumping arises 1 to 3 hours after meals full of carbohydrates and it is associated with feelings of weakness, hunger, and mental confusion. Most sufferers can control dumping syndrome by eating six small meals daily instead of three larger ones; by choosing foods which are full of protein and lower in carbohydrate; by chewing the meals completely; by drinking fluids between instead of with meals.

Alternatives

Antrectomy is not the very first type of treatment for either peptic ulcer disease or GAVE till by 2003. It is almost always restricted to patients with repeated bleeding or other conditions for example malignancy, perforation, or obstruction. Although surgery, including antrectomy, is easily the most common treatment for stomach cancer, it will always be essential to mix it with chemotherapy, radiation treatment, or biological therapy (immunotherapy). The reason behind a mix of treatments is the fact that stomach cancer is hardly ever found early. Its first symptoms in many cases are moderate and easily mistaken for that the signs of heartburn or perhaps a stomach virus. Consequently, cancer has often spread beyond the stomach when it's identified.

Medication

Treating peptic ulcers brought on by H. pylori has transformed its concentrate recently from lowering the amount of acidity within the stomach to clearing away the bacterium. Since not one antibiotic works well in curing H. pylori infections, so-called triple therapy commonly includes a mixture of a couple of antibiotics to get rid of the bacterium along with a medicine to reduce acid production along with a third medicine this is usually bismuth subsalicylate to safeguard the stomach lining. Specific kinds of medications which are included in triple therapy or relief of distress include:

• Complementary and alternative (CAM) approaches
• Sucralfate. Sucralfate is really a compound of sucrose and aluminum that handles ulcers having a protective coating which allows eroded tissues to recover.
• Antacids. These compounds can be found as OTC tablets or liquids.
• H 2 blockers. They are used as well as antibiotics in triple therapy to lessen gastric acid secretion. H 2 blockers consist of cimetidine, ranitidine, famotidine, and nizatidine. Some can be found as over-the-counter (OTC) medicines.
• Bismuth subsalicylate. Sold being an OTC underneath the trade name Pepto-Bismol, medicines has some antibacterial effectiveness against H. pylori in addition to safeguarding the stomach lining.
• Proton pumps inhibitors. These medicines include drugs for example omeprazole and lansoprazole. They're directed at suppress manufacture of gastric acid.
• Prostaglandins. They are directed at treat ulcers made by several pain medicines referred to as NSAIDs. Prostaglandins safeguard the stomach lining in addition to lower acid secretion. The best-known prescription medication on this category is misoprostol.
  

Complementary and alternative approaches which have been accustomed to treat gastric ulcers associated with PUD include acupuncture, Ayurvedic medication, and herbal preparations. Ayurvedic medication, that is the standard medical system of India, classifies people based on metabolic physique. Individuals who fit in with the kind referred to as pitta are thought especially vulnerable to ulcers and given dieting that emphasizes "cooling" foods, including vast amounts of vegetables. In Japanese medicine, ulcer remedies produced from licorice or bupleurum are often prescribed. Western herbalists suggest arrangements containing fennel, fenugreek, slippery elm, or marshmallow root along with licorice to alleviate the pain sensation of stomach ulcers.

Endoscopy

Endoscopy may be used for treatment in addition to diagnosis. About 10 different procedures have been in use by 2003 for treating bleeding ulcers and AVMs by using an endoscope; the most typical involve the injection of epinephrine or perhaps a sclerosing solution; the use of a thermal probe towards the bleeding area; or even the utilization of a Nd:YAG laser to coagulate outdoors arteries. Watermelon stomach has become treated more regularly with argon plasma coagulation compared to an antrectomy. Recurrent bleeding, however, happens in 15-20% of ulcers given endoscopic techniques.