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腹腔镜减重手术【英文讲义】

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Laparoscopic Weight Reduction Surgery
DR AKRAM ALLOUBANI
G. SURGEON, JORDANIAN BOARD

Member of world association of laparoscopic surgeons
Diploma in Minimal Access surgery
Project Submitted Towards Completion Of Diploma In Minimal Access Surgery, World Laparoscopy Hospital, Gurgaon, NCR Delhi, India. Sep 2007.
Click Here to Use Our BMI Calculator
Abstract Obesity is a major health care problem, In U. S .A. 30 million overweight, 7 million morbidly obese. Cost for management of Bariatric comorbidities in  states $ 100 billion  annually
Weight reduction surgery is performed by either the open or laparoscopic approach, improves health outcomes of morbidly obese patients by leading to substantial weight loss with relatively low rates of adverse events.
In my study, Iam discussing different approach of laparoscopic Weight reduction operations, comparing between technique, advantage, disadvantage, complication and long term benefit.

Key words
Obesity, Laparoscopic approachs,bariatric , comparison

Introduction:
Morbid obesity is defined as a body mass index (BMI) greater than 40 kg/m2. The prevalence of morbid obesity in the U.S. is 6% for women and 2% for men; morbid obesity is associated with a shortened life span. For example, a morbidly obese man at age 20 can expect to live 13 years less than his counterpart with a normal BMI, which equates to a 22% reduction in life expectancy.
Classification of obesity
Obesity class            BMI (kg/m2)
Underweight!                 18.5
Normal                         18.5–24.9
Overweight                   25.0–29.9
Mild obesity I                30.0–34.9
Moderate obesity II       35.0–39.9
Severe obesity III          R40.0
Materials and methods: A literature search was performed using search engine Google, HighWire Press, SpringerLink and library facility available at laparoscopic hospital. The following search terms was used: laparoscopic _ bariatric.
Criteria for selection of papers were upon statistical way of analysis, institute if they were specialized for laparoscopy, the way of management and the technique of operations
Pathophysiology
- Not Clear
- Genetic Factor
- Metabolism
- Endocrine regulation
- Psychosocial & cultural
The basic mechanism is  (( Energy Intake > Energy output ))
Complications of obesity
Risk Factor for:
1- Coronary artery disease
2- Type II Diabetes Mellitus.
3- Hypertension.
4- Dyslipidemia.
5- Gallbladder disease
6- GERD.
7- Arthritis of W t bearing joints
8- Obstructive Sleep apnea
9- Psychosocial & Socioeconomic
10- Certain Malignancies
Treatment
  • Non -surgical
The first treatment of morbid obesity involves dietary and lifestyle changes. Although this strategy may be effective in some patients, frequently the weight loss is not durable, with only 5%-10% of patients able to comply with lifestyle modifications on a long-term basis.
  • Conventional ( Non pharmacological)
Diet
Physical exercise
Behavioral therapy
  • Pharmacological treatment  
2   Surgical Treatment:

is the only effective long-term treatment for patients with morbid obesity .When conservative measures fail; some patients may consider surgical approaches. A 1991 National Institutes of Health (NIH) Consensus Conference defined surgical candidates as those BMI of greater than 40 kg/m2, or greater than 35 kg/m2 in conjunction with severe co morbidities such as cardiopulmonary complications or severe diabetes. (2) Super obesity has been described as a BMI greater than 50 kg/m2
Indication for Surgery in M. O
1. BMI of 40 & more
2. BMI of 35 – 40 with obesity related co morbidities
    e.g.  D.M., HTN, Severe arthritis, Sleep apnea Syndrome.
3. No history of alcohol or drug abuse.
4. Age over 18 & under 55 years
Contraindications
Significant psychiatric disorders
- Endocrine problem
- Inflammatory bowel disease
- Severe Organic disease.
Criteria for surgical therapy:
1. Safe, as little invasive as possible.
2. Highly efficient i.e. 50% of excess W t. eliminated within 5 Years.
3. The operative risk should be lower than the risk of natural evolution of the disease
4. Carry few long term Complications
Evaluation of patient prior to surgery:
Multidisciplinary Team:
- Nutritionist
- Anesthesiologist
- Endocrinologist
- Psychiatrist.
- Surgeon
Rationale For Laparoscopic Surgery for M.O.
1. Reduce Wound – related complications.
2. Shorten hospital stay.
3. Decrease postoperative pain
4. Improve respiratory function.
5. Faster convalescence
Types of Operations for M. O.
I. Gastric restrictive procedures
      *Lap. Vertical banded gastroplasty.
      *Lap. Adjustable gastric Banding
II.Malabsorptive Procedure
      *Biliopancreatic diversion + duodenal switch , jejuno-ileal Bypass
|||.mixed procedure
      *R – Y Gastrojejunostomy
1) Laparoscopic Vertical Banded Gastroplasty (VBG)
- Described in 1994 by Hess .
- Purely restrictive procedure with no Malabsorptive component .
- Relatively simple operation with low operative risk.
-Techniques:
  In this procedure the stomach is segmented along its vertical axis. To create a durable reinforced and
rate-limiting stoma at the distal end of the pouch, a plug of stomach is removed and a propylene collar is
placed through this hole and then stapled to itself. Because the normal flow of food is preserved,
metabolic complications are rare

                               
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Adjustable Gastric Banding
- It is the least invasive surgical treatment of Morbid obesity.
-  Described in 1993 by Catona .
- It is purely restrictive procedure .
- In Europe ,it is the bariatric procedure of choice.
- In U.S.A. ,FDA approval since June 2001 .
-Techniques
Adjustable gastric banding involves placing a gastric band around the exterior of the stomach. The band
is attached to a reservoir that is implanted subcutaneously in the rectus sheath. Injecting the reservoir with
saline alters the diameter of the gastric band; therefore, the rate limiting stoma in the stomach can be
progressively narrowed to induce greater weight loss, or expanded if complications develop. Because the
stomach is not entered, the surgery and any revisions, if necessary, are relatively simple

                               
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Malabsorptive Procedures
There are multiple variants of malabsorptive procedures, which differ in the lengths of the alimentary limb, the biliopancreatic limb, and the common limb, where the alimentary and biliopancreatic limb are anastomosed. These procedures also may include an element of a restrictive surgery based on the size of the stomach pouch. The degree of malabsorption is related to the length of the alimentary and common limbs.
  • Biliopancreatic Bypass Procedure (also known as the Scopinaro procedure)
The biliopancreatic bypass (BPB) procedure, developed and used extensively in Italy, was designed to address some of the drawbacks of the original intestinal bypass procedures that have been abandoned due to unacceptable metabolic complications. Many of the complications were thought to be related to bacterial overgrowth and toxin production in the blind, bypassed segment. In contrast, BPB consists of a subtotal gastrectomy and diversion of the biliopancreatic juices into the distal ileum by a long Roux-en-Y procedure. The procedure consists of the following components:

    • A distal gastrectomy functions to induce a temporary early satiety and/or the dumping syndrome in the early postoperative period, both of which limit food intake.
    • A 200-cm long "alimentary tract" consists of 200 cm of ileum connecting the stomach to a common distal segment.
    • A 300- to 400-cm "biliary tract," which connects the duodenum, jejunum, and remaining ileum to the common distal segment.
    • A 50- to 100-cm "common tract," where food from the alimentary tract mixes with biliopancreatic juices from the biliary tract. Food digestion and absorption, particularly of fats and starches, are therefore limited to this small segment of bowel, creating a selective malabsorption. The length of the common segment influences the degree of malabsorption.
    • Because of the high incidence of cholelithiasis associated with the procedure, patients typically undergo an associated cholecystectomy.
  • Biliopancreatic Bypass with Duodenal Switch -
The duodenal switch procedure is essentially a variant of the biliopancreatic bypass described above. However, instead of performing a distal gastrectomy, a "sleeve" gastrectomy is performed along the vertical axis of the stomach, preserving the pylorus and initial segment of the duodenum, which is then anastomosed to a segment of the ileum, similar to the above procedure, to create the alimentary limb. Preservation of the pyloric sphincter is intended to ameliorate the dumping syndrome and decrease the incidence of ulcers at the duodenoileal anastomosis by providing a more physiologic transfer of stomach contents to the duodenum. The sleeve gastrectomy decreases the volume of the stomach and also decreases the parietal cell mass. However, the basic principle of the procedure is similar to that of the biliopancreatic bypass; i.e., producing selective malabsorption by limiting the food digestion and absorption to a short common ileal segment.
  • Distal (Long Limb) Gastric Bypass (Roux or alimentary limb > 150 cm  
Recently variations of gastric bypass procedures have been described, consisting primarily of long limb Roux-en-Y procedures, which vary in the length of the alimentary and common limbs. For example, the stomach may be divided with a long segment of the jejunum (instead of ileum) anastomosed to the proximal gastric stump, creating the alimentary limb. The remaining pancreaticobiliary limb, consisting of stomach remnant, duodenum, and length of proximal jejunum is then anastomosed to the ileum, creating a common limb of variable length in which the ingested food mixes with the pancreaticobiliary juices. While the long alimentary limb permits absorption of most nutrients, the short common limb primarily limits absorption of fats. The stomach may be bypassed in a variety of ways, either by resection or stapling along the horizontal or vertical axis. Unlike the traditional gastric bypass, which is essentially a gastric restrictive procedure, these very long limb Roux-en-Y gastric bypasses combine gastric restriction with some element of malabsorptive procedure, depending on the location of the anastomoses.
    . For gastric restrictive procedures, the weight loss is primarily due to reduced caloric intake, and thus the patient must be committed to eating small meals, reinforced by early satiety. For example, gastric restrictive surgery will not be successful in patients who consume high volumes of calorie rich liquids. In patients undergoing biliopancreatic bypass, reduced intake may not be as much of an issue, but patients must adhere to a balanced diet to avoid metabolic complications. In addition, the high potential for metabolic complications requires life-long follow-up. Surgeons need to be adequately trained in the particular techniques and should perform a high volume of these procedures.
Laparoscopic Roux --En –Y Gastric Bypass (GBP )
- Described in 1994 by Wittgrove.
- It is a restrictive procedure with malabsorptive component .
- It is the procedure of choice in superobese ,sweet eaters & in patients with GERD
  • – Technique
The original gastric bypass surgeries were based on the observation that post-gastrectomy patients tended to lose weight. The current procedure, gastric bypass with horizontal or vertical partition of the stomach in association with a Roux-en-Y procedure (i.e., a gastrojejunal anastomosis). Thus the flow of food bypasses the duodenum and proximal small bowel. The procedure may also be associated with an unpleasant "dumping syndrome," in which a large osmotic load delivered directly to the jejunum from the stomach produces abdominal pain and/or vomiting. The dumping syndrome may further reduce intake, particularly in "sweets eaters. Because the normal flow of food is disrupted, there are more metabolic complications compared to other gastric restrictive procedures,  all of which can be corrected by oral supplementation. Another concern is the ability to evaluate the "blind" bypassed portion of the stomach. Gastric bypass may be performed with either an open or laparoscopic technique.

                               
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Surgical Complications :
Surgery                                                             Early                                                           Late
Roux-en-Y gastric bypass                       Pulmonary embolus                                 Anastomotic stricture
                                                                Anastomotic leak                                      Marginal ulcer
                                                                Deep venous thrombosis                          Gastrointestinal bleeding
                                                                Gastrointestinal bleeding                           Dumping syndrome
                                                                Wound infection                                         Anemia
                                                                Enterocutaneous fistula                             Neuropathy-B12 deficiency
                                                                Small bowel obstruction                             Dermatitis
                                                                Sepsis                                                        Hair loss
                                                                Respiratory failure                                      Weight gain
                                                                                                                                   Incisional hernia
                                                                                                                                   Small bowel obstruction
                                                                                                                                   Osteoporosis
                                                                                                                                    Malnutrition
Duodenal switch                                       Similar to Roux-en-Y gastric bypass         Bile salt wasting
                                                                                                                                    Diarrhea-secretory
                                                                                                                                   Malabsorption
                                                                                                                                   Vitamin deficiency
                                                                                                                                   Dermatitis
Laparoscopic adjustable gastric band       Gastric prolapse                                       Band erosion
                                                                  Band slippage                                           Port migration
                                                                  Band malposition                                      Port infection
                                                                  Gastric occlusion                                      Disconnection of port tubing
                                                                  Esophageal dilation Malnutrition

Lap. Vertical banded gastroplasty.           erosion of the polypropylene mesh
                                                                  enlargement of the pouch,                        stomal stenosis,
                                                                                                                                    reflux esophagitis,
                                                                                                                                    mild vitamin deficiencies


Discussion:
The criteria of efficacy of any surgey and benefit depend on many factor such as :
Weight Loss
Durability of weight loss
Short-term complications
Reoperation Rate
Long-term complications
Improved health outcomes in terms of weight-related comorbidities
*Lap. Vertical banded gastroplasty.
There are numerous clinical series that report substantial amounts of weight loss following vertical
banded gastroplasty. weight loss of 75% to 100% of excess weight in first one year. But vertical banded
gastroplasty has largely been abandoned as longer term, less favorable outcomes have been reported in
the literature.  While initial results in terms of weight loss, complications and improvement in co morbid
conditions were good, these results deteriorated over time . The rate of revision surgery was 29.51% due
to inadequate weight loss or complications. Also the procedure was less successful in the super obese
patient  .
*Adjustable Gastric Banding
A major advantage of the LAGB is its safety. also Lower perioperative morbidity and mortality, gradual
weight loss with few nutritional complications, and reversibility make LAGB is a good option .LAGB was
associated with a median overall morbidity rate of 11.3% with a mean short-term mortality of 0.05%,
compared with a 23.6% morbidity and 0.5% mortality for RYGB . Short operative time and hospital stay
also is good advantage .
Weight loss after LAGB (especially in sweet eater) is significantly slower than after
RYGB, so comparisons between the operations demonstrate superior
weight loss with RYGB . also The need for frequent adjustments is sometimes considered as
disadvantage .
The ability to place a band laparoscopically in the massively super obese and in the older morbidly obese
patient. offers significant advantages .
Laparoscopic Roux --En –Y Gastric Bypass (GBP )
Laparoscopic Roux-en-Y gastric bypass is fast becoming the gold standard for treatment of refractory
morbid obesity. The magnitude of weight loss can be achieved quickly , hospital stay about
3- 4 days, but long operation time ,need good skills and its irriversaple and risk of leak and
malabsorption is high .
The Duodenal Switch Operation
The magnitude of weight loss that occurs after the duodenal switch procedure is better than that
achieved after the Roux-en-Y gastric bypass procedure.
The mortality and morbidity of the duodenal switch are comparable to other common weight loss

procedures, also minimal dietary limitations and metabolic sequelae.also risk of leak is low as
compaered RYGB surgey
The only limitation is long operation time ,long hospital stay , need good skills and its
irriversaple.
.Conclusion:
1.Bariatric Surgery is an effective option for sustained  w t. Loss in M. O.
2. Long term result from Lap. Bariatric operations should be similar to those of open.
3. Lap. Approaches for treatment of M.O. are now available for all bariatric operations.
4. Lap. ASGB is emerging as an alternative bariatric surgical option to VBG ,& GBP .
5. The criteria used for selecting a patient for a particular operation are still based on   surgeon`s experience , training & preference.
6. Further studies are required to define subgroups of patients who will benefit from a particular operation.
7. The Lap. Malabsorptive procedure is still experimental until further data support it`s safe
References
  • BlueCross BlueShield Association Medical Policy Reference Manual, Policy No. 7.01.47
  • National Institutes of Health: National Heart, Lung, and Blood Institute. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults. The Evidence Report. September 1998; No. 98-4083
  • Consensus Development Panel. Gastrointestinal surgery for severe obesity. Ann Int Med 1991;115:956-61
  • TEC Assessment: Bariatric Surgery for Morbid Obesity, 2003; BlueCross and BlueShield Association Technology Evaluation Center  www.bcbs.com/tec/vol18/18_10.html  (Verified 12/12/06)
  • MacLean LD, Rhode BM, Forse RA. Late results of vertical banded gastroplasty for morbid and super obesity. Surgery 1990;107(1):20-27
  • Willbanks OL. Long term results of silicone elastomer ring vertical gastroplasty for the treatment of morbid obesity. Surgery 1987;101(5):606-10
  • Brolin RE. Results of obesity surgery. Gastroentrol Clin North Am 1987;16:317-35
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  • Balsiger BM, Poggio JL, Mai J et al.  Ten and more years after vertical  banded gastroplasty as primary operation for morbid obesity. J Gastrointest Surg 2000;4(6):598-605
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  • National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweightand obesity in adults: the evidence report. Obes Res 1998;6:51S–209.
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