腹腔镜Nissen胃底折叠主要降低胃酸反流的量和潜在提高粘膜的完整性到中间食管神经损伤的儿童食管联合检测

Laparoscopic Nissen fundoplication mainly reduces the volume of acid reflux and potentially improves mucosal integrity up to the middle esophagus in neurologically impaired children detected by esophageal combined

Abstract
BACKGROUND:
The aim of this study was to evaluate detailed changes of gastroesophageal reflux disease (GERD) in children before and after laparoscopic Nissen fundoplication (LNF) utilizing esophageal combined pH-multichannel intraluminal impedance (pH/MII) measurements.

PATIENTS AND METHODS:
Thirteen patients with neurological impairment, who received laparoscopic Nissen fundoplication (LNF) owing to refractory pathological GERD, were enrolled in this study. 24h pH/MII was conducted in all patients before and one year after LNF. Each parameter of the pH/MII was evaluated and compared each other.

RESULTS:
Both the mean pH index and bolus exposure index after LNF were significantly lower than those before LNF. The mean numbers of total and nonacid reflux episodes after LNF were significantly lower than those before LNF. The mean numbers of total, acid and nonacid proximal reflux episodes after LNF were significantly lower than those before LNF. The mean baseline impedance values from Z3 to Z6 after LNF were significantly higher than those before LNF.

CONCLUSIONS:
The present study provides new insights into the effects of LNF in pediatric patients, which prevents mainly acid reflux episodes from rising to the proximal esophagus, and is expected to improve the mucosal integrity up to the middle esophagus.

KEYWORDS:
Baseline impedance; Gastroesophageal reflux; Laparoscopic Nissen fundoplication; Multichannel intraluminal impedance measurements; Neurologically impaired children

Laparoscopic Nissen fundoplication mainly reduces the volume of acid reflux and .pdf (449.81 KB, 下载次数: 0)

2016-12-6 08:58 上传

点击文件名下载附件
腹腔镜Nissen胃底折叠主要降低胃酸反流的量和潜在提高粘膜的完整性到中间食管神经损伤的儿童食管联合检测