术中单剂量静脉注射右旋酮洛芬氨丁三醇和双氯芬酸钠在腹腔镜胆囊切除术术后镇痛效果的比较

术中单剂量静脉注射右旋酮洛芬氨丁三醇和双氯芬酸钠在腹腔镜胆囊切除术术后镇痛效果的比较
Comparison of postoperative analgesic efficacy of intraoperative single-dose intravenous administration of dexketoprofen trometamol and diclofenac sodium in laparoscopic cholecystectomy

Abstract
摘要
STUDY OBJECTIVE:
研究目的：
The aim of this study is to compare the effects of intravenous single-dose dexketoprofen trometamol and diclofenac sodium 30 minutes before the end of the surgery on relief of postoperative pain in patients undergoing laparoscopic cholecystectomy.
这项研究的目的是在腹腔镜胆囊切除术患者的术后疼痛，手术结束前30分钟静脉注射单剂量右旋酮洛芬氨丁三醇和双氯芬酸钠的效果进行比较。

DESIGN:
设计：
A randomized fashion.
一个随机的方式。

SETTING AND PATIENTS:
设置和病人:
Sixty (American Society of Anesthesiologist class I-II) patients undergoing laparoscopic cholecystectomy were divided into 2 groups
腹腔镜胆囊切除术六十例（美国麻醉医师协会I-II类），随机分为2组。

INTERVENTION:
干预:
Patients in group DT received 50 mg dexketoprofen trometamol, whereas patients in group DS received 75 mg diclofenac sodium, intravenously 30 minutes before the end of surgery.
DT组患者接受50毫克右旋酮洛芬氨丁三醇，而在DS组患者接受75毫克双氯芬酸钠，手术前30分钟静脉注射。

MEASUREMENTS:
测量：
Postoperative pain intensity, morphine consumption with patient-controlled analgesia, time to first analgesic requirement, complications, rescue analgesic (intravenous tenoxicam 20 mg) requirement, and duration of hospital stay were recorded.
术后疼痛强度，吗啡消耗量与病人自控镇痛，首次镇痛要求，并发症，镇痛（静脉注射替诺昔康20毫克）的要求，和住院时间的记录。

MAIN RESULTS:
主要结果：
Postoperative pain visual analog scale scores were similar in the follow-up periods (P > .05). Patient-controlled analgesia morphine consumption was significantly less in group DT compared with group DS in all postoperative follow-up periods (2 and 4 hours: P < .01; 8, 12, 18, and 24 hours: P < .001). In the postoperative period, the first analgesic requirement time was significantly longer in group DT compared with group DS (P < .01). In addition, the number of patients requiring rescue analgesic was higher in group DS compared with group DT (P < .01). Other follow-up parameters were similar.
术后疼痛视觉模拟量表评分在随访期内相似（P＞.05）。病人自控镇痛吗啡消耗量显著减少，DT组在术后随访期间DS组相比（2和4小时，P＜.01；8，12，18，和24小时：P < .001）。在术后镇痛的要求，第一时间与DS组比较DT组明显延长（P＜.01）。此外，需要镇痛药的患者数量在DS组高于DT组相比（P＜01）。其他后续参数是相似的。

CONCLUSION:
结论：
In our study, administration of intravenous single-dose dexketoprofen trometamol 30 minutes before the end of surgery provided effective analgesia with reduced consumption of opioids and requirement for rescue analgesic compared with diclofenac sodium in patients undergoing laparoscopic cholecystectomy. For this reason, we believe that, as a part of multimodal analgesia, dexketoprofen trometamol provides more effective analgesia than diclofenac sodium in patients undergoing laparoscopic cholecystectomy.
在我们的研究中，前30分钟静脉注射单剂量右旋酮洛芬氨丁三醇管理，手术结束为降低消耗提供了有效的镇痛，在腹腔镜胆囊切除术中应用阿片类药物与对镇痛药的需求比较。因此，我们认为，作为多模式镇痛的一部分，右旋酮洛芬氨丁三醇提供了与更有效的镇痛药双氯芬酸钠在腹腔镜胆囊切除术比较。

原文：
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术中单剂量静脉注射右旋酮洛芬氨丁三醇和双氯芬酸钠在腹腔镜胆囊切除术术后镇痛效果的比较